Due to its efficiency in accessing complex heterocyclic structures in one step, multicomponent reactions (MCRs)1 have been widely adapted in organic research and industry. Following the same trend, the number of undergraduate organic laboratory experiments using MCRs2 has also increased in recent years. MCRs have the advantage of conserving most of the atoms from the building blocks that are present in the product to generate libraries of compounds in an efficient manner. Therefore, MCRs can be used to introduce the concept of combinatorial chemistry as a tool utilized in drug discovery to the undergraduate laboratory curriculum.2e,3