Abstract. We investigated the DNA restriction fragment length polymorphism of the major histocompatibility complex class II genes: HLA-DRB, -DQA, -DQB, DPA, -DPB, the serologically defined HLA-A, B, C, DR an- tigens, and the primed lymphocyte typing defined HLA- DP antigens in 23 Danish patients with primary biliary cirrhosis (PBC) and in healthy Danes.