In further work, we attempt to determine whether YAP/TAZ can affect SSc development through regulating Hippo, Notch, Wnt/β-atenin, and TGF-β/Smad pathways.In summary, this work demonstrates that knockdown of YAP/TAZ represses inflammation and fibrosis of SSc mice, thereby alleviating SSc progression. Thus, this work suggests that YAP/TAZ may be a potential target for SSc treatment.