All case infants had continuous multichannel electroencephalogram (EEG) recorded, initiated within the first 24 hours of life. The EEG was recorded and reviewed as previously described.11 Grade of encephalopathy, if any, was assigned at 24 hours after birth by a dedicated research fellow (B.W.), using the modified Sarnat score.12 Standardized neurologic assessment was additionally performed on day 3 and at discharge.13 Case infants were divided into those with HIE (graded mild, moderate, or severe), and those with biochemical or clinical signs of perinatal asphyxia, but without clinical encephalopathy.
All case infants had continuous multichannel electroencephalogram (EEG) recorded, initiated within the first 24 hours of life. The EEG was recorded and reviewed as previously described.11 Grade of encephalopathy, if any, was assigned at 24 hours after birth by a dedicated research fellow (B.W.), using the modified Sarnat score.12 Standardized neurologic assessment was additionally performed on day 3 and at discharge.13 Case infants were divided into those with HIE (graded mild, moderate, or severe), and those with biochemical or clinical signs of perinatal asphyxia, but without clinical encephalopathy.
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