Increasing SPO2 by IV injection does not address the removal of carbon dioxide from patients, which is another essential function of the lungs. This may mean for some extremely severe cases, where patients have complete loss of lung function, the delivery of IV oxygen nanobubble treatment needs to be more carefully monitored as there may be an increased risk of hypercapnia. Clinically providing high SPO2 in a low volume of IV liquid may be crucial in the case of COVID-19 patients where the need maintain patients at the lower limits of hydration to reduce lung lavage is preferred. It could be applied in a controlled manner to augment lung function to get patients through the critical phase of the infection.