黄桂红等进一步研究表明，鬼针草黄酮能够显著改善棕榈酸+胰岛素联合诱导的

Further studies Huanggui Hong et show Bidens flavonoids can significantly improve palmitate + insulin and induced Hep G2 cells in the IR state, which may be related through upregulation PI3Kp85 mRNA expression, increased GLUT4 mRNA and protein expression of the AKT1 insulin signaling reducing the negative feedback regulation, activation of PI3K / Akt pathway

Further studies such as Huang Guihong have shown that the mechanism of hep G2 cell IR, which can be significantly improved by palmitic acid and insulin combined induction, may be related to the reduction of negative feedback regulation of AKT1 to insulin signaling by increasing PI3Kp85 mRNA expression, increasing GLUT4 mRNA and protein expression, and reducing the negative feedback regulation of AKT1 to insulin signaling, activating the PI3K/Akt pathway.

Huang Guihong et al. Further study showed that Bidens bipinnata flavone can significantly improve the IR state of HepG2 cells induced by palmitic acid and insulin, and its mechanism may be related to its ability to up regulate the expression of pi3kp85 mRNA, increase the expression of GLUT4 mRNA and protein, reduce the negative feedback regulation of AKT1 on insulin signal transduction, and activate the PI3K / Akt pathway<br>