We present herein the preparation of novel polymer inclusion membranes (PIMs) containinginsoluble β-CD polymer as a carrier, polyvinyl chloride as a base polymer, and dibuthylphtalate(DBP) as a plasticizer in varying proportions. The prepared PIMs can be obtained by a simple,fast, and high-yield preparation process. Physicochemical characterizations of such membranesoccurred in a homogeneous structure. In addition, Fourier-transform infrared Spectroscopy (FT-IR)analysis found that DBP was inserted between these polymeric chains by non-covalent interactions.This led to a spacing of PVC/poly(β-cyclodextrin) chains inducing a better access of guest moleculesto PIM cyclodextrins. To achieve the elimination of ibuprofen and progesterone, two examples ofemerging environmental contaminants that can lead to possible alterations to aquatic environmentsand affect human health, the effect of three operating parameters was studied (pH, the proportion ofβ-cyclodextrin polymer, and wastewater agitation). The proportion of β-cyclodextrin polymer andwastewater agitation had a favorable influence on drug extraction at 10 ppm. The PIMs containingβ-cyclodextrin polymer was unstable in basic conditions and was more effective at acidic pH.These initial results demonstrate the high potential for drug extraction of this polymer.