Objective: To explore the current situation of accidental needle stabbing and the harm to physical and mental health caused by various causes caused by clinical care workers, analyze its causes and propose relevant coping and prevention programs. Methods: To consult the relevant literature to understand the degree of accidental needle stabbing research, and analyze and summarize. Results: According to the relevant research analysis, the main reasons leading to accidental needle stabbing in clinical care personnel are: weak self-protection consciousness, irregular operation, environmental and psychological factors, clinical nursing staff failed to pay high attention to needle stabbing, and the hospital did not provide standardized training on needle stabbing, increasingly tense working atmosphere, easy to lead to needle stabbing. The corresponding prevention and coping plan is put forward for the various causes of needle stabbing. Conclusion: Nursing staff should pay more attention to accidental needle stabbing, and work out an efficient prevention and coping plan for the causes of accidental needle stabbing, so as to provide a good working environment for clinical nursing staff, ensure personal safety, and minimize the occurrence of accidental needle stabbing.