Heavier symptoms and signsA further rise in intraluminal pressure、 Venous obstruction ,The swelling of the appendix is obvious, Further edema and ischemia in the appendix、Bacterial invasion through the wall of appendix The surface is covered with cellulose (purulent) exudate,The mucosal ulcer surface enlarges and reaches the muscular layer and the serosal layer. There are small abscesses in each layer of the wall, and there is a pus in the cavity.