We did not find that the TAKE strate

We did not find that the TAKE strategy was noninferior to the HOLD strategy for the primary outcome of $30% of sessions with IDH. In the TAKE group, we saw a slight decrease in the proportion of patients with $30% of sessions with IDH during the intervention period (19%) compared with baseline (20%). The larger change was in the HOLD group, where the proportion of patients with $30% of sessions with IDH decreased from 17% at baseline to 11% during the intervention. However, we found that the TAKE strategy was superior to the HOLD strategy with respect touncontrolled hypertension, definedaspredialysis systolic BP .160 mm Hg. Whether any potential benefit of holding BP medications on reducing IDH is offset by any potential harms related to having higher predialysis BP requires further study. The pilot Blood Pressure in Dialysis study randomized patients on hemodialysis to a standardized or intensive predialysis systolic BP target (achieved systolic BP approximately 156 mm Hg versus approximately 145 mm Hg, respectively), and found no difference in left ventricular mass, but more IDH and adverse cardiovascular events in the intensive BP-lowering group