This study primarily examined the clinical treatment of plus-flavored shimbuto in patients with positive diabetic nephropathy of the kidney. METHODS: Forty-two patients with positive renal deficiency diabetic nephropathy treated at our hospital from January 2010 to June 2011 were removed and randomly divided into two groups, a control group and an observation group. Treatment was performed using commonly used Western medicine, and the observation group was treated with Kami-shimbuto based on this, and the results of the two sets were compared with the treatment index of Kampo medicine. Results: From the therapeutic effect, 90.48% in the observation group and 57.14% in the control group, and the comparative difference between the groups was clear and statistically significant (P).