High intraperitoneal volumes ofdextrose 5% require high doses of insulin to prevent severehyperglycaemia, causing major electrolyte disturbances during perfusion. Other carrier solutions that have been investigated are hypertonic solutions, hypotonic solutions and isotonic high molecular weight solutions. The main disadvantage of hypertonic solutions is dilution of the drug due to fluid shift towards the peritoneal cavity. Both in vitro and animal studies suggest that the use of hypotonic solutions can enhance platinum accumulation in tissue