Surface modification is a widely used and effective strategy to improve the biocompatibility of materials surfaces with out changing the mechanical properties of the bulk biomaterials, including covalent bonding, physical adsorption and biological methods[13].Among them,as a versatile and easy-to-use technology,layer-by-layer(LBL)self-assembly of compact and stable polyelectrolyte multilayers has been explored for use in biomedical applications[24–26].