For example, in healthier skin with

For example, in healthier skin with a mostly young phenotype — and, typically, a lower chronological age such as in its 20s — the extracellular matrix needs powerful, active protection to help prevent oxidative damage before it becomes entrenched for decades. In unhealthier skin with a more aged phenotype, in its 40s or 50s, damaged support proteins need to be repaired and replaced.