This research was the first of its kind about family caregiving and spirituality in a palliative care setting in Pakistan. By listening to families talk about their experiences and the concerns they had while caring for their terminally ill family member, I was able to gather new knowledge about family caregivers’ spirituality in the hospice setting. This new knowledge will potentially guide healthcare professionals when addressing spiritual concerns of family caregivers and developing culturally relevant spiritual care intervention during end of-life care in Pakistan.