Cognitive debriefing and expert discussionThe LC-PROM was regarded as clear and concise, easyto understand and easy for the patients in the cognitivedebriefing to complete. Completion time was 10 min onaverage. Considering patients’ suggestions, we madesome modifications to the instrument. Six items in PHD that described atypical symptoms and overlapped witheach other were deleted. Symptoms in deleted items included, for example, oliguria, dry eyes, pale skin andmucosa, among others. We also replaced the words“hepatic region” with “right upper abdomen,” to makethis text easier to understand. Similarly, two items werereduced in PSD, one item was reduced in TRD, andone item was added in SOD.