Objective At present little informa

Objective At present little information is available to helpdefine whether a certain degree of pelvic organ prolapseis clinically relevant. We performed a retrospective studyto define cut-offs for significant pelvic organ descent onthe basis of prolapse symptoms.Methods At a tertiary urogynecological center, 735women with symptoms of lower urinary tract dysfunctionand prolapse were seen for interview, clinical examination, multi-channel urodynamics and ultrasound imaging,while supine and after voiding, for prolapse quantification. Women with multi-compartment prolapse, i.e. thosein whom no compartment was clearly dominant wereexcluded. Receiver–operator statistics were used to testpelvic organ descent as a predictor of prolapse symptoms.