Previous studies have shown that when periodontal tissue is in a continuous inflammatory state, the osteogenic differentiation ability of bone marrow mesenchymal stem cells, periodontal ligament stem cells, and other cells decreases, affecting the effectiveness of periodontal bone regeneration 13,15,16; Meanwhile, inflammatory cytokines such as TNF secreted by immune cells- α It will increase the activity of osteoclast and promote alveolar bone resorption53.
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