Survival was adequate for analysis and there was no difference in surv的简体中文翻译

Survival was adequate for analysis

Survival was adequate for analysis and there was no difference in survival amongst neratinib- treated mice compared to controls. There were decreased body weights in the 20 and 50 mg/kg/day-treated males and in 125 mg/kg/day-treated females. Clinical signs included decreased activity, hunched posture, thin appearance, tremors, ungroomed fur, changes in respiration (labored, shallow, and/or increased), apparent hypothermia (cold to touch), dehydration, and/or decreased feces. Mild incidences of cellularity or inflammation were observed at 50 mg/kg in males and 125 mg/kg in females. No drug-related neoplasms were identified in this study following daily oral administration of neratinib.
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生存期足以进行分析,与对照组相比,经neratinib治疗的小鼠的生存期无差异。在20和50 mg / kg /天治疗的雄性和125 mg / kg /天治疗的雌性中,体重下降。临床体征包括活动减少,弯腰的姿势,外表瘦弱,震颤,无毛的毛皮,呼吸变化(劳力,浅和/或增加),体温过低(感冒),脱水和/或粪便减少。在男性中为50 mg / kg,在女性中为125 mg / kg,观察到细胞增多或炎症的轻度发生。每天口服neratinib后,在该研究中未发现与药物相关的肿瘤。
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Survival was adequate for analysis and there was no difference in survival amongst neratinib- treated mice compared to controls. There were decreased body weights in the 20 and 50 mg/kg/day-treated males and in 125 mg/kg/day-treated females. Clinical signs included decreased activity, hunched posture, thin appearance, tremors, ungroomed fur, changes in respiration (labored, shallow, and/or increased), apparent hypothermia (cold to touch), dehydration, and/or decreased feces. Mild incidences of cellularity or inflammation were observed at 50 mg/kg in males and 125 mg/kg in females. No drug-related neoplasms were identified in this study following daily oral administration of neratinib.
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结果 (简体中文) 3:[复制]
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存活率足以进行分析,尼拉替尼治疗组小鼠的存活率与对照组相比没有差异。20和50 mg/kg/天治疗组雄性和125 mg/kg/天治疗组雌性体重下降。临床症状包括活动减少、驼背、体形瘦削、颤抖、毛发无毛、呼吸变化(劳累、浅和/或增加)、明显低温(冷接触)、脱水和/或粪便减少。在50毫克/千克的雄性和125毫克/千克的雌性中观察到轻微的细胞性或炎症发生率。每日口服尼拉替尼后,本研究未发现与药物相关的肿瘤。<br>
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