These proteins included inflammatory markers (serum amyloid A [SAA] and plasminogen activator inhibitor-1 [PAI-1]), extracellular matrix remodeling proteins (metalloproteinase -9 [MMP-9]) and growth factors (hepatocyte growth factor [HGF]), as well as soluble signaling proteins (soluble glycoprotein 130 [sgp130]; interleukin-2 receptor-alpha [IL-2Rα], interleukin-6 receptor 1 [IL-6R1], and soluble tumor necrosis factor receptor 1 [TNFR1]).