pre-treatment with the Ginkgolide B (GB) or Bilobalide (BB) protected SH-SY5Y cells against α-Syn-induced cell viability decreases, and reduced cell apoptosis after aggregated α-Syn stimulation. Together, wefirstly find that aggregated α-Syn induced cell apoptosis and GB and BB may attenuate aggregated α-Syn-inducedcell apoptosis, which gives us an insight into the novel therapy for PD in future