While QS is important for the forma

While QS is important for the formation of a fully mature biofilm, c-di-GMP was shown responsible for the initial adherence and early stages of biofilm formation, as a switch from a planktonic to a biofilm lifestyle. Christensen et al.77 showed that decreasing the c-di-GMP level in P. aeruginosa by over-expressing a PDE enzyme resulted in biofilm dispersal, validating c-di-GMP signaling as a target for new anti-infectives.