synthesis, and nucleic acid synthes

synthesis, and nucleic acid synthesis as well as the interference with bacterial metabolism or cell membranes.14 Several antibiotic classes acting via one of these mechanisms are in current use for the treatment of P. aeruginosa infections, especially aminoglycosides (e.g., tobramycin), fluoroquinolones (e.g., ciprofloxacin), polymyxins (e.g., colistin), and the β-lactam antibiotics cephalosporins (e.g., ceftazidime), carbapenems (e.g., meropenem), penicillins plus β-lactamase inhibitors (e.g., piperacillin-tazobactam), and the monobactam aztreonam.15,16 For every type of infection (e.g., pneumonia, bacteremia, meningitis) recommendations exist suggesting a specific agent or in most of the cases a combination of at least two antibiotics.15,16