The widespread use of portable electric and electronic devices increases the need for efficient autonomous power supplies that replace the currently predominant battery technology. The use of common fuels/chemicals (hydrocarbons or alcohols) as energysources is a promising alternative when combined with the recent developments in microchannel reactor technology. The high power density, rapid start-up time, and low-temperature operation of PEMFC make these devices as the most promising for poweringup electric or electronic devices. However, an essential requirement for the reformate-fed PEMFC is the removal of CO from the H2 stream after the reforming and water–gas shift (WGS) reactions. After the WGS units the CO content of the hydrogen streams may vary between ca. 0.5 and 2 vol.% being, therefore, mandatory clean-up units for the removal of CO to trace level. Preferential CO oxidation (CO-PROX) is among the preferred technologiesfor small-scale fuel processor applications [1]. CO-PROX reactions allow reducing CO contents from 1% in the feed to the ppm level.