BTK is an important part of B cell antigen receptor signal transduction cascade, which involves the proliferation, maturation, differentiation, apoptosis and cell migration of B cell development. Because BTK plays a key role in the progress of B-cell lymphoproliferative diseases, it has become an attractive drug research target for the treatment of B-cell malignant tumors in recent years. BTKI is an important therapeutic drug for B-cell lymphoma.