Clinically, the isolation and purification of bacteria, the detection of bacterial culture characteristics and biochemical tests were used to obtain the clinical strains of escherichia coli. The results of drug susceptibility test showed that the drug resistance of escherichia coli varied in different regions, and there were also different degrees of resistance of escherichia coli to antibacterial drugs in the same region, and the drug resistance of escherichia coli increased generally, and some drugs could not be used for clinical treatment basically.