通过这种方法测定，发现了肿瘤细胞在角蛋白重组后，细胞力学变化较大，在通

As measured by this method, tumor cells were found to have greater changes in cell mechanics after keratin reorganization and were also more easily deformed when passing through areas of limited area (Fig. 5B). At the same time, its deformability was also affected by lysophosphatidic acid. Adhesion is a more complex process than cell deformation. However, theoretical models can still be established through physical mechanics and mathematical methods. While it is not possible to fully simulate the physiological state, it is useful to compare adhesion between different cells or between different drugs. When two deformable objects stick together, applying an external force to separate them results in deformation of their contact area. According to the degree of deformation and the strength of the external force, it can be determined according to the Johnson-Kendall-Roberts (JKR) theory. Figure 5C shows the process from adhesion to separation between two cells. The adhesion energy between mouse sarcoma cells was quantified by the strong adhesion force generated by high-concentration dextran solution. Although there is currently no theory based on the adhesion between immune cells and tumor cells, to calculate the adhesion force under different conditions. However, quantifying the adhesion of different adhesion molecules to different cancer cells and different immune cells will surely promote the development of precision cancer therapy and genetic engineering.

Through this method, it was found that after keratin recombination, the cell mechanics of tumor cells changed greatly, and they were more likely to deform when passing through areas with limited area (Fig. 5b). At the same time, its deformability is also affected by lysophosphatidic acid. Compared with cell deformation, adhesion is a more complex process. However, the theoretical model can still be established by physical mechanics and mathematical methods. Although it is impossible to completely simulate the physiological state, it is helpful to compare the adhesion between different cells or different drugs. When two deformable objects adhere, the application of external force to separate them will lead to the deformation of their contact area. According to the degree of deformation and the strength of external force, it can be determined according to Johnson Kendall Roberts (JKR) theory. Figure 5C shows the process from adhesion to separation between two cells. The adhesion energy between mouse sarcoma cells was quantified by the strong adhesion produced by high concentration dextran solution. Although there is no theory to calculate the adhesion under different conditions based on the adhesion between immune cells and tumor cells. However, quantifying the adhesion of different adhesion molecules to different cancer cells and different immune cells will promote the development of cancer precision treatment and genetic engineering.

Through this method, it was found that after the keratin recombination, the cell mechanics of tumor cells changed greatly, and it was easier to deform when passing through the limited area (Figure 5B). At the same time, its deformability is also affected by lysophosphatidic acid. Compared with cell deformation, adhesion is a more complicated process. However, the theoretical model can still be established by physical mechanics and mathematical methods. Although it is impossible to completely simulate the physiological state, it is helpful to compare the adhesion between different cells or different drugs. When two deformable objects are stuck, applying external force to separate them will cause the deformation of their contact areas. According to the degree of deformation and the strength of external force, it can be determined according to Johnson-Kendall-Roberts (JKR) theory. Fig. 5C shows the process from adhesion to separation between two cells. The adhesion energy between mouse sarcoma cells was quantified by the strong adhesion produced by high concentration dextran solution. Although there is no theory to calculate the adhesion between immune cells and tumor cells under different conditions. However, quantifying the adhesion of different adhesion molecules to different cancer cells and different immune cells will certainly promote the development of precise cancer treatment and genetic engineering.