间的其他物理外部作用，不产生化学键，制备过程中也不发生均相酸分解反应，

Other physical interaction between the external, not chemical bonds, the manufacturing process is not homogeneous acid decomposition reaction occurs, so the bioavailability of oleanolic acid greatly increased, and further, according to Jiang Zhaohui prodrug theory, structural oleanolic acid modification of the dicarboxylic acid monoester formed cs-oh converted to the disodium salt, disodium salt of making a water-soluble prodrug, oleanolic acid have been synthesized disodium succinate, disodium horse oleanolic acid maleate monoester, cyclohexane oleanolic acid monoester disodium original preliminary pharmacological experiments oleanolic acid monoester disodium phthalate showed that the protective effect of sodium on experimental liver injury and oleanolic acid different degree of improvement. The high dose of oleanolic acid does not increase the liver damage, side effects are likely to change from oleanolic acid pharmaceutical dosage forms, improve the bioavailability of oleanolic acid drugs, improve efficacy.

Other physical external effects, do not produce chemical bonds, the preparation process does not occur in the process of homogenic acid decomposition reaction, so the biological utilization of zizepech acid greatly improved, further, according to the theory of pre-drugs such as jiang Zhaohui, aligned with the structure of pyrochloric acid for structural modification, the single ester formed dichloric acid cs-oh into disodium salt, 使其成为水溶性的前药二钠盐,齐墩果酸已被合成琥珀酸二钠、齐墩果酸二钠马来酸单酯、环己烷齐墩果酸单酯原二钠、齐墩果酸单酯邻苯二甲酸二钠初步药理实验结果表明,钠对实验性肝损伤的保护作用与齐墩果酸改善程度不同。 And high-dose zigbic acid will not aggravate liver damage, side effects may also be from the zigacid drug dosage type changes, improve the bioavailability of zironic acid drugs, improve the efficacy.

There is no chemical bond and homogeneous acid decomposition reaction in the preparation of oleanolic acid. Therefore, the bioavailability of oleanolic acid is greatly improved. Further, according to the prodrug theory such as Jiang Zhaohui, the structure of oleanolic acid is modified, and the dicarboxylic acid CS Oh formed by monoester is converted into disodium salt, which is a water-soluble prodrug disodium salt. Oleanolic acid has been The preliminary pharmacological experiments of disodium succinate, disodium oleanolate maleate, disodium cyclohexaneoleanolate and disodium oleanolate phthalate showed that the protective effect of sodium on experimental liver injury was different from that of oleanolic acid. However, high dose of oleanolic acid will not aggravate the liver injury, and the side effects may be changed from the dosage form of oleanolic acid to improve the bioavailability of oleanolic acid and improve the curative effect.<br>