Objective to compare the efficacy of new drug a in patients with type 2 diabetes mellitus whose blood glucose can not be effectively controlled by diet and exercise, and whether it is better than placebo treatment at the dose of 12 mg / day for 16 weeks, while it is not inferior to the efficacy of acigliptin benzoate 25 mg / day. 16 patients with type 2 diabetes mellitus in a hospital were randomly assigned to the experimental drug group, positive control group or placebo group in the ratio of 2:1:1, and were treated according to the administration scheme. The therapeutic effect and various test indexes of the three groups were compared. According to the prevention and treatment guidelines for type 2 diabetes mellitus, glycosylated hemoglobin is the gold standard for evaluating blood glucose control, so it is necessary to improve the quality of blood glucose control It is used as the main index in this study. After treatment, the levels of fasting blood glucose (FPG) and glycosylated hemoglobin (HbA1c) in the experimental group and the control group were significantly decreased (P < 0.05), the fluctuation of the placebo group was not significant, and the experimental group was lower than the control group (P < 0.05), the difference was statistically significant (P < 0.05). A new drug a is more effective than agliptin benzoate in the treatment of type 2 diabetes mellitus whose blood glucose can not be effectively controlled by diet and exercise.<br>
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