Note that most compounds were consi

Note that most compounds were considered suitable for a PDE, i.e.,a limit derived based on a non-linear MOA, although many of thesecompounds have been considered by some to be “mutagenic”. Forstyrene and epichlorohydrin, the AI was derived by linear extrapolation.It was noted that for epichlorohydrin the forestomach tumors onwhich the AI was based were not likely to be relevant to humans at lowdoses so that the AI is highly conservative. A PDE was also derivedbased on forestomach tumors and hyperplasia for comparison. For thesetwo compounds the non-linear derived compound-specific toxicologylimit was similar (within 5-fold) to the linear-derived limit.